If you have Immune disorder Histamine or problems with Allergy you must watch these You tube movies regarding mast cells

See this interesting article we extracted  regarding Histamines which is related to Methylation from DR Jill also copy and paste this complete study on histamine below this line 
​http://ajcn.nutrition.org/content/85/5/1185.full.pdf

Dr Mercola has an interesting site as well
http://articles.mercola.com/sites/articles/archive/2013/04/18/allergy-season.aspx

 Healthy Updates from Dr. Jill, Your Functional Medicine Expert!
 
16 November 2013 Histamine Intolerance: Could this be the cause of your problems?
Photo courtesy of www.freedigitalphotos.net

Histamine is found lurking primarily in aged, cured, fermented, cultured, and spoiled foods. From a survival perspective, it is imperative that humans have avoided rotting flesh.  When animals die, bacteria from the gastrointestinal tract leaks out and starts digesting proteins.  Some of the amino acids from the proteins are converted by bacterial enzymes to bioactive amines, the chief of which is histamine (formed from amino acid histamine)   At low levels, histamine increases stomach acid, which helps kill off any bacteria we may be exposed to.  However, at high levels, histamine may trigger nausea, diarrhea, heart palpitations and dilation of blood vessels may cause a severe headache.   

The Anatomy of a Histamine Reaction Within minutes a person exposed to histamine may experience: Flushing of face Nausea Headache Runny nose or congestion Dizziness Racing heart Anxiety If the reaction continues, these symptoms may occur: Hives Generalized swelling Abdominal cramps  Diarrhea And in severe cases, there may be: Panic attacks Blurred vision Bronchoconstriction, asthma or difficulty breathing Laryngeal edema or swelling of tongue


Biogenic Amines... Histamine is one of them! A biogenic amine is a potent signaling molecule made from an amino acid. Histamine, for example, is made from the common amino acid histidine (amino acids are what proteins are made of). Meat and fish are rich in protein, so they are chock full of amino acids.

Here is a list of the most common biogenic amines and the amino acids they are made from.
Arginine—Agmatine, Putrescine, Spermine, Spermidine Histidine—Histamine Lysine—Cadaverine Ornithine—Putrescine, Spermine, Spermidine Phenylalanine—Phenylethylamine Tryptophan—Tryptamine, Serotonin Tyrosine–Tyramine
Many species of bacteria and yeast contain the enzyme histidine decarboxylase (HDC), which turns histidine into histamine or other biogenic amines into their active form. When meat or fish is not immediately consumed or frozen, bacteria get straight to work breaking down the amino acids within it, and one of the by-products is histamine.


For those who are sensitive to histamines, it is essential to eat your meat/fish fresh or confirm that it was frozen quickly. Seems simple enough, right? But wait, there’s more.  Many people go out of their way to ferment foods on purpose!  We add bacteria to milk to make cheese and yogurt. We add yeast to grapes to make wine. We add bacteria to meat to make salami. In the process, these fresh foods—milk, grapes, and meat—which in their fresh forms are essentially histamine-free, become very high in histamine and other biogenic amines.  Not a problem... unless you have histamine intolerance!
Histamine intolerance is the intolerance towards “normal” levels of histamine in food caused by a decreased activity of the histamine-degrading enzymes diamine oxidase (DAO) or histamine N-methyltransferase (HNMT). In the gut the main enzyme is DAO while in other parts of the body like the skin and brain the enzyme HNMT degrades histamine. 
Pseudo-allergy from Histamine Toxicity
Dietary biogenic amines are not limited to rotten meat and spoiled fish.  They are present in aged cheese, red wine, chocolate, which are all common migraine triggers.  And the meat we consume is not the only problem with bacteria.  Another problem comes because we all have a myriad of microbes living in our guts.  When these populations become imbalanced as in the case of bacterial overgrowth, like SIBO (small intestinal bacterial overgrowth) or yeast overgrowth, the microbes in our gut can also contribute to producing too much histamine as well.  Many people who suffer from histamine intolerance have either deficiencies in DAO enzyme production (which breaks down histamine) or excess of bacteria and yeast that have become histamine production factories in the gut.

What exactly  is Histamine Intolerance?
In a 2007 review article we read that histamine intolerance affects at least 1% of the population, and 80% of those affected are middle-aged.  “The term “histamine intolerance” was introduced as common denominator for symptoms such as abdominal pain, flatulence, diarrhoea, headache, itching, swelling of the eyes,  hives, runny nose, painful periods, difficulty breathing, racing heart, palpitations and low blood pressure occurring after the consumption of histamine-rich foods,” according to article written in 2011 by Komericki.

Histamine intolerance may be caused by abnormally low levels of DAO. DAO is found, among other places, in the membranes of cells lining the small intestine and the upper portion of the colon, therefore people with damaged gastrointestinal systems seem to be at higher risk for histamine intolerance.

Women are more commonly affected than men by histamine intolerance. This may be because estrogen and histamine reinforce each other—histamine can increase estrogen levels and vice versa, which may explain why histamine intolerance is associated with pre-menstrual cramps and menstrual migraine and even uterine fibroids.  Pregnant women may experience relief from food sensitivities during pregnancy because the placenta secretes very high amounts of diamine oxidase, or DAO, the enzyme that destroys histamine.

So What Causes Histamine Intolerance?  Common causes include
Inflammatory bowel diseases (or anything that causes damage to the enterocytes -the cells that line the gut) Celiac disease Intestinal dysbiosis Small Intestinal Bacterial Overgrowth (SIBO) Parasitic infections, like Giardia Leaky gut or increase in intestinal permeability Alcohol or other DAO inhibitors Excess biogenic amines in diet Medications that increase histamine Food allergies Genetic polymorphisms, like MTHFR and others that lower DAO, MAO, ALDH Vitamin cofactor deficiencies - enzymes, like DAO and MAO rely on vitamin co-factors and deficiencies these can also cause abnormal enzyme activity
Helpful Hints in Dealing with Histamine Intolerance:
First treat any intestinal dysbiosis (imbalance of the gut microbes) - these could involve any of the following: Fungal dysbiosis Small intestinal bacterial overgrowth (SIBO) Bacterial infections Parasitic infections Lack of healthy probiotic bacteria  Heal leaky gut  Supplement with l-glutamine, aloe, DGL, or other gut healing supplements Avoid common food allergens  Take strains of probiotic that decrease histamine production Lactobacillus rhamnosus and bifidobacter may decrease histamine production while lactobacillus case may actual increase it Try natural antihistamines Ascorbic Acid  1000-5000mg daily - helps degrade histamine Vitamin B6 50-100mg daily - important for synthesis of DAO enzyme Quercetin - 3-6grams daily (powdered works best) - natural antihistamine/mast cell stabilizer Increase the activity of enzyme DAO Try taking DAO enzyme, Histame with meals Decrease histamine input Avoid alcoholic beverages Avoid raw and cured sausage products such as salami. Avoid processed fish products. Use freshly caught fish and seafood instead. Avoid pickles Avoid citrus fruits.  Avoid chocolate Avoid nuts Avoid products made with yeast and yeast extracts Avoid soy sauce and fermented soy products Avoid black tea and green tea Avoid energy drinks and coffee Avoid matured cheese (hard cheese). Use cream cheese, mild cheese and cottage cheese instead. Avoid spinach in large quantities Avoid tomatoes, ketchup and tomato sauces Avoid artificial food colorings & preservatives Avoid certain spices: Cinnamon, Chili powder, Cloves, Anise, Nutmeg, Curry powder, Cayenne Avoid medications that contribute to histamine release such as vasodilators Try medications that block histamine H1 blockers, like loratadine H2 blockers, like ranitidine Cromolyn sodium Read this article for more on how methylation can affect histamine production

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References and resources

http://www.ncbi.nlm.nih.gov/pubmed/17490952
http://www.allergynutrition.com
http://thelowhistaminechef.com
Posted by Jill Carnahan, MD at 10:54 AM 
Labels: allergies, anxiety, biogenic amines, dizziness, flushing, food allergies, headaches, his tame, histamine, histamine intolerance, hives, leaky gut, MTHFR gene mutation, panic attack, racing heart, yeast
14 comments: Kristie MMay 31, 2014 at 8:18 AM What do you suggest for treating SIBO? I have a prescription for rifaximin but my gut tells me that it is not the right treatment for me. I have been working on my health and seeing doctors for around 4 years, and have taken antibiotics already for suspected gut infection. (I felt terrible on them and the bloating never went away.) I am way better than I was 4 years ago, and have addressed many of the root causes. One of the last remaining symptoms was bloating so I had the breath test for SIBO and it came out positive. I had started to realize that histamines were probably causing some of my worst problems. I have been on a low histamine diet. I really think something like wormwood/black walnut hull would help me. I feel that histamine/allergies and SIBO are the problems, but unsure how to go about addressing it. I was recently on herbal antibiotics and felt badly on them! I have to be careful about killing off things as it seems to overwhelm my detox capacity. Any thoughts would be appreciated! Reply Jill Carnahan, MDMay 31, 2014 at 10:23 AM Hi Kristie - check this out by blog article on SIBO... http://www.jillcarnahan.com/2014/05/16/6-signs-sibo-might-root-cause-ibs/ Reply Victoria sJuly 27, 2014 at 2:31 AM Hello, could you please provide some more information about the use of prebiotics and probiotics and histadelia/histamine intolerance and SIBO parasitic infections. For me it's streptococcus and blastocystis, but you may prefer to comment more generally). Many thanks , Victoria Reply Jill Carnahan, MDJuly 27, 2014 at 5:48 AM Hi Victoria, You might enjoy this article on treating SIBO... http://www.jillcarnahan.com/2014/05/16/6-signs-sibo-might-root-cause-ibs/
warmly
Dr Jill Reply Obgyn el caminoDecember 3, 2014 at 12:36 AM This is totally awesome.Although variety of article on this topic,this article contains some of the precious points which can never be read in other articles. Reply AnonymousJanuary 1, 2015 at 4:47 PM Histamine/Salicylate sufferers AVOID these Probiotics; 

Lactobaccilus Casei and also L. Lactis, L.Reuteri, L. Fermentum/Fermenti, L. Paracasei, L.Thermophilus, L. Faecum/Faeclis, L.Bulgaricus & Strep Thermophilus & 

B. Lactis is excellent, but L. Lactis can release Histamine. 

Probiotics YOU NEED TO BE ON: L. acidophilus as well as (MOST important) L.Rhamnosus, L.Salivarius, L.Planatarum -- these last 3 are super important and can be purchased as a 3-in-1 combination from Allergy Research Group, sold on Amazon.com and shipped 2-day to ensure freshness

Also, take a separate Bifidobacterium Probiotic -- that contains B. Lactis, also known as B. Animalis. 

Also, B.Longus B. Brevi, and B. Infantis are also extremely helpful and do not need refrigeration like the above 3-in-1 combo I suggested that does need to be refrigerated. 

Also avoid products containing alcohol in any form and parabens proplys etc., AND also avoid shampooing hair in shower as anything that comes in contact with our skin enters our bloodstream within 30 seconds and can cause a reaction, sometimes a delayed reaction hours later. Hope this helps. Reply AnonymousJanuary 2, 2015 at 12:58 PM Thanks for the info Anonymous. 

I agree, L.Lactis & L.Casei (and a few other PB's) are known to release more Histamine into our system, aggravating the condition and worsening the suffering. 

Your post also applies to Excema sufferers as well not just those with Histamine Intolerance. 

PB's are safe for infants and babies as well though maybe check first with a holistic Pediatrician. Mainstream doctors aren't big on PB's, just Antibiotics. 

I took the good PB's while pregnant a few years ago (2x per-day) and sure glad I did. I did not have a flare up while pregnant and my 3 yr old son is perfectly healthy as well -- no Histamine problems or rashes or Excema or problems for him. Reply nancySeptember 27, 2015 at 1:54 PM I looked on amazon for the probiotics from allergy research on amazon. The 3 in 1 you talked about. What is the name of it. I am having problems figuring out which on you are talking about Reply
Replies
AnonymousNovember 25, 2015 at 8:36 PM Sorry for the delay in reply - lost my bookmarks. 

They are manufactured by Allergy Research Group: 

Lactobacillus -- 
L. plantarum / L. rhamnosus / L. salivarius

This 3-in-1 combo is not histamine-releasing and are excellent. 

Maybe you can get them from a health food store or ask them to order them for you ... OR order direct from the manufacturer. 

NOTE: these probiotics must be refrigerated at all times, even during shipping.
Reply Jill Carnahan, MDSeptember 27, 2015 at 4:02 PM Hi Nancy
You cannot purchase from Amazon but you can direct from manufacturer here (https://www.protherainc.com/prod/proddetail.asp?id=V770-06) using code: 618 Reply AnonymousSeptember 30, 2015 at 12:33 PM Glad I have found your site - most helpful :-)
Does the above company ship to the UK? Reply Jill Carnahan, MDSeptember 30, 2015 at 12:56 PM I am not sure, but you can call them at 1-888-488-2488 Reply JamesOctober 26, 2015 at 9:29 PM This is great resource as I try to undue my recently developed histamine intolerance. (I think due to too many of the wrong bacteria.) A question for the community: I'm interested in restoring my gut microbiota and I'm happily working with diet and muddy veggies. I see also lots of suggestions for kimchi, sauerkraut, kombucha, etc. But since I have a histamine intolerance, I try to avoid fermented foods, and I don't want bacteria that make amines to take up residence in my gut. Aside from dirt, where else can I get good bacteria? Reply Jill Carnahan, MDOctober 27, 2015 at 6:32 AM Hi James,
you likely have SIBO (small intestine bacterial overgrowth) which contributes to histamine production and intolerance of certain foods. You are right that you should avoid fermented food as they will trigger histamine issues. You might try a spore-forming probiotic as they are usual well tolerated, like Prothera BioSpora (https://www.protherainc.com/prod/proddetail.asp?id=K-BSP) You can order direct from Prothera with code: 618 Reply
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